Desai is the grandniece of Manmohan Desai. Vaishali was brought up in Bangalore. Vaishali did her schooling in Sophia High School, Bangalore. She finished her graduation in Psychology in Mount Carmel College, Bangalore. After her Miss India contest she shifted her base permanently to Mumbai along with her family not only for modeling but also for her further studies.She has two sisters named Jaituni Desai and Hariyali Desai. Jaituni Desai is also a model and was a contestant in Miss India contest in 2006.
Vaishali was doing ramp shows in Bangalore and was a top model. Her first show was when she was only sixteen. But her major break and entry in the acting world was with her first commercial for Ponds Dreamflower Talc. And later was seen in ads like Tanishq, Compaq, Raymonds.Vaishali has however not changed her name to Vyshalee Desai as given in her debut film Kal Kissne Dekha and shall continue with her original name Vaishali Desai.
 Modelling and Advertisements
Vaishali was seen first in a Ponds commercial after which did a Tanishq commercial followed by an Indian Oil Campaign. She was then seen in a Compaq laptop ad and in the very famous Raymond ad and is now being seen in another Tanishq ad with Nafisa ali. She has also done ads down south, for products like Swarnam Oil, Power detergent, etc.Vaishali was seen in an ad with Shah Rukh Khan for Sunfeast and also in a Dabur Gulabari ad.Vaishali did her first video for Kumar Sanu for the song Aisa na dekho Mujhe. Later she did three videos for the very famous Band Euphoria (Indian band). She did Soneya with them which was followed by Mehfuz which was directed by Pradeep Sarkar.Vaishali had participated in the Elite Look of the Year contest in 2004 and was the 2nd runner-up in it. In 2005 Vaishali participated in the Pond's Femina Miss India contest and was the third runner-up becoming the Miss India International even though she wasn't in the 5 finalists. Vaishali then left in the same year for the Miss International contest in Tokyo, but failed to win due to her having conjunctivitus.Vaishali has done various ramp shows for top Indian designers. She has participated in the Lakme Fashion week, Dhaka Fashion,Sri Lankan Fashion week.And done shows for L'Oreal,moschino,etc. She has also done a lot of print work as well as editorial work.
Vaishali's big break came in Bollywood with her film Kal Kissne Dekha.She was the lead actress in the Vashu Bhagnani produced romantic-thriller Kal Kisne Dekha which released in India on June 12, 2009.
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